Typically, the nanoparticles are targeted tumors by being covered sublimation in molecules that spe

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Engineers at MIT have developed nanoparticles with three layers that take the tumors due to their acidic environment and with positive charges escapes into the cancer cells so they can poison them. If successfully tested in mice. By Mette Jensen Buck May 20, 2011 at. 13:00
Typically, the nanoparticles are targeted tumors by being covered sublimation in molecules that specifically bind with proteins, which sits on the surface of cancer cells. But according to MIT researchers are challenges of this approach, as it is difficult to find the right target protein that is found in all cancer cells within a tumor, but not in healthy sublimation tissue. sublimation An objective which operates in a kind of cancer might seem with another.
Polymer coating (light blue) is thrown when the particle approaches a tumor, revealing its positively charged surface. This charge gets absorbed through the membranes of tumor cells. (Illustration: Stephen Morton)
The American researchers decided sublimation instead to exploit the fact that a lower pH is around tumors due to the increased metabolism. Tumor cells grow and divide for faster than normal cells, and the metabolic activity uses up a lot of oxygen, which increases acidity as the tumor grows. Positively charged surface sublimation
Extremely they have a layer of polyethylene to protect them from being degraded in the bloodstream. However, they are designed so that the outer layer comes off when they get into it a little more acidic environment surrounding the tumors.
This exposes the next layer, sublimation which is positively charged, and hence the particles are able to penetrate the individual negatively charged membranes of tumor cells. The particles may be positively charged from the beginning, as in the state can also damage normal tissue.
The scientists were the first in mice shown that the particles are able to survive in the bloodstream for 24 hours and accumulate in the tumors and enter the tumor cells. This is the first time anyone has successfully tested nanoparticles sublimation that exploit the low pH in living animals.
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There will be a fomodentlig signifkant amount back blood after uptake into tumors, and if nanoparticle is still active, the positively charged surface allow penetrerering of other cells in the blood, liver or kidney where the toxic effect that could be triggered?
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