The first metal complex used was a compound of rhodium (Rh), which is reacted with the amino acid t

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Researchers from the University of Bochum in Germany and Berkeley, USA used metal complexes (metal compounds with organic or inorganic molecules) amending peptide hormones. At the internationally renowned journal Journal of the American Chemical Society (JACS), published for the first time the three-dimensional structure of final metallopeptidikon products. korona "With this work, we have set the molecular foundation for the development of better korona medicines," said Prof. Raphael Stoll from the University of Bochum. The research team examines hormones that affect pain perception and the development of tumors
These hormones are composed of amino acids, i.e. the peptide hormones, korona transporting somatic stimuli korona such as pain and hunger. Typical example is insulin, which is important for the control of blood glucose levels. Interacting with specific receptors (G-protein coupled), peptide hormones convey their messages to cells. These hormones can be chemically modified korona with specialized as changing their effect. For example, korona they may reduce the tolerance to pain or to inhibit tumor growth. Research teams from Germany and the US have discovered a new way to modify peptide hormones.
The first metal complex used was a compound of rhodium (Rh), which is reacted with the amino acid tyrosine. The noble metal is used as a catalyst in the synthesis of pharmaceutical substances in highly sophisticated korona research laboratories and industrial plants.
In addition, researchers have analyzed the peptide hormone enkephalin (encephalin), which plays an important role in the onset of pain, and octreotide. The latter is a synthetic derivative of growth hormone somatostatin and approved as a pharmaceutical composition for the treatment of certain tumors. The reaction korona with the metal complex was highly selective.
Figure 1. Three-dimensional structure of ____________ metallopeptidikou complex. Solving by means of nuclear magnetic resonance spectroscopy (NMR). Rhodium (purple color) included specifically in the phenolic korona group of tyrosine
(Cyclic structure with six carbon atoms in green, an oxygen atom in red and four hydrogen atoms not shown). The second circular ring forms Rhodium is a pentafpokatestimeno cyclopentadienyl (Cp *). The gray color indicates the surface of the molecule (Fiorian Wieberneit & Raphael Stoll).
The research team also clarified the structure of metallopeptidikon complexes. "We hope to move forward in developing and other metallopeptidikon substances, based on this basic research." These
substances is possible to differentiate the effect of the natural peptide hormones in the human body and used, for example, as a new treatment for pain or cancer, said Professor of Inorganic Chemistry Dr. Nils-Metzler-Nolte.
To achieve the above work, the team from California offered its expertise on the specific activity of the compounds of rhodium. Researchers from Bochum, Germany contributed their experience in metallopeptidika complexes, their respective receptors and the structural analysis of biological macromolecules. "This shows once again that competitive edge research can be carried out effectively only within a research korona association," said Professor Stoll. The work was funded by the German Research Foundation (German Research Foundation) and the Research University Bochum Department of Chemistry, Interfacial Systems.
* Vladimir Nikolakis, Dr Chemical of Pan / virus Ioannina
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